… In this study, we explored the role of oral tolerance and … of IgA nephropathy (IgAN), an
important form of nephritis in … sion of oral tolerance, which otherwise develops after chronic oral …

… the formation of potentially nephritogenic immune complexes … that the process of oral tolerance
occurs in healthy humans (… in the hematuria of experimental IgA nephropathy. Lab Invest …

… : IgA nephropathy (IgAN). Diverse as these two examples are, they do not represent the
clinical extremes of IgAN, namely, the acute nephritic syndrome with acute renal failure, and the …

… involved in the generation of nephritogenic IgA will help us explain the … uteroglobin (UG)-deficient
mouse models display a number … of experimental IgAN after oral immunization with …

… on the experimental system, however, oral tolerance can be … of mucosal tolerance apparently
exerts a nephritogenic effect by … Nephritis does not develop in complement-deficient mice …

… induction of a defective mucosal tolerance [17]. A disrupted … In a pilot experiment, we reported
that mice fed with standard … a possible role of oral tolerance breakdown in various immune-…

… These experiments show that defective oral tolerance, by permitting persistence ofIgG …
promotes nephritis, complement-fixing IgG and IgM co-deposits are critical for nephritogenesis in …

… the role that defective clearance plays in IgA nephritogenesis have not … Defective oral
tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization…

… The hallmark of IgA nephropathy (IgAN) is macroscopic hematuria coinciding with, or …
The role of mucosal pathogens has been proven in different experimental models. Mucosal (or …

… in the generation of nephritogenic IgA, formation of IgA-IC and their … Defective oral tolerance
promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization…